diff --git a/tox.ini b/tox.ini
index 8633c8d..90003e7 100644
--- a/tox.ini
+++ b/tox.ini
@@ -5,9 +5,11 @@
 # Set STATSD env variables so that statsd code paths are tested.
 setenv = STATSD_HOST=localhost
          STATSD_PORT=8125
+         VIRTUAL_ENV={envdir}
 deps = -r{toxinidir}/requirements.txt
        -r{toxinidir}/test-requirements.txt
-commands = nosetests --logging-format="%(asctime)s %(name)-32s %(levelname)-8s %(message)s" {posargs}
+commands =
+  python setup.py testr --slowest --testr-args='{posargs}'
 
 [tox:jenkins]
 downloadcache = ~/cache/pip
@@ -16,7 +18,8 @@
 commands = flake8
 
 [testenv:cover]
-setenv = NOSE_WITH_COVERAGE=1
+commands =
+  python setup.py testr --coverage
 
 [testenv:pyflakes]
 deps = pyflakes